Table 1 Selected Chk1 substrates identified in this screen
From: A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
Protein name | Gene name | Phospho-site identified |
|---|---|---|
Alpha-adducin | ADD1 | KKFRTPSFLKKSK (S726) |
Rho guanine nucleotide exchange factor 2 | ARHGEF2 | GLRRILSQSTDSL (S172) |
Uncharacterized protein C10orf47 | C10orf47 | SSSRSRSFTLDDE (S43) |
Calmodulin-regulated spectrin-associated protein 2 | CAMSAP1L1 | GITRSISNEGLTL (S464) |
Coiled-coil domain-containing protein 49 | CCDC49 | GYTRKLSAEELER (S337) |
Cell division cycle 2-like protein kinase 5 | CDC2L5 | SRSRHSSISPSTL (S437) |
RNA polymerase-associated protein CTR9 homolog | CTR9 | RPRRQRSDQDSDS (S1081) |
Flap endonuclease 1 | FEN1 | VLMRHLTASEAKK (T195) |
Golgin subfamily A member 4 | GOLGA4 | LQLRVPSVESLFR (S71) |
General transcription factor 3C polypeptide 1 | GTF3C1 | RLVRNLSEEGLLR (S667) |
Zinc finger protein 40 | HIVEP1 | SSKRMLSPANSLD (S1749) |
Heterogeneous nuclear ribonucleoprotein M | HNRNPM | GMDRVGSEIERMG (S432) |
Importin subunit alpha-2 | KPNA2 | LKRRNVSSFPDDA (S54) |
LIM domain only protein 7 | LMO7 | IMRRGESLDNLDS (S1510) |
Microtubule-associated protein 4 | MAP4 | RLSRLATNTSAPD (T925) |
Matrin-3 | MATR3 | QLKRRRTEEGPTL (T150) |
| Â | Â | FDDRGPSLNPVLD (S195) |
Myb-binding protein 1A | MYBBP1A | LVIRSPSLLQSGA (S1310) |
Probable E3 ubiquitin-protein ligase MYCBP2 | MYCBP2 | VFQRSYSVVASEY (S3440) |
Nance-Horan syndrome protein | NHS | KLRRRKTISGIPR (T380) |
Nuclear pore complex protein Nup153 | NUP153 | DAKRIPSIVSSPL (S330) |
O-GlcNAc transferase subunit p110 | OGT | PTKRMLSFQGLAE (S20) |
Oxysterol-binding protein-related protein 11 | OSBPL11 | ISQRRPSQNAISF (S189) |
PHD finger protein 8 | PHF8 | EGTRVASIETGLA (S904) |
Pleiotropic regulator 1 | PLRG1 | KIQRMPSESAAQS (S119) |
Protein phosphatase methylesterase 1 | PPME1 | HLGRLPSRPPLPG (S15) |
Protor-1 | PROTOR1 | LLRRSRSGDVLAK (S240) |
RNA-binding protein 7 | RBM7 | IIQRSFSSPENFQ (S136) |
RNA-binding protein 14 | RBM14 | SDYRRLSESQLSF (S618) |
| Â | Â | SFRRSPTKSSLDY (T629) |
Telomere-associated protein RIF1 | RIF1 | NKVRRVSFADPIY (S2205) |
60S ribosomal protein L19 | RPL19 | PQKRLASSVLRCG (S12) |
Sentrin-specific protease 2 | SENP2 | LLRRKVSIIETKE (S344) |
Paired amphipathic helix protein Sin3a | SIN3A | QIRRHPTGTTPPV (T432) |
Serine/arginine repetitive matrix protein 2 | SRRM2 | QTPRPRSRSPSSP (S1497) |
| Â | Â | PRPRSRSPSSPEL (S1499) |
TBC1 domain family member 4 | TBC1D4 | VIQRHLSSLTDNE (S485) |
| Â | Â | MRGRLGSVDSFER (S588) |
Treslin (C15orf42) | TICRR | ALIRHKSIAEVSQ (S865) |
| Â | Â | SVQRVHSFQQDKS (S1045) |
Transcription intermediary factor 1-beta, KAP1 | TRIM28 | GVKRSRSGEGEVS (S473) |
TRIP12 protein | TRIP12 | GLARAASKDTISN (S1078) |
ATP-dependent DNA helicase 2 subunit 1, Ku70 | XRCC6 | FTYRSDSFENPVL (S477) |
Nuclear-interacting partner of ALK | ZC3HC1 | FFSRVETFSSLKW (T84) |
Zinc finger protein 395 | ZNF395 | SPVRSRSLSFSEP (S447) |