Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage

Table 1 Summary of mouse mammary tumor models

Model	Number of tumors	Promoter	Strain	Reference
Basal
C3(1)/SV40 T/t-antigens	5	C3(1)	FVB	[20]
p53^fl/fl ;MMTV-cre transplant	7	MMTV	Balb/C	[21]
BRCA1^fl/fl;p53^+/-;MMTV-cre	5	MMTV	129B6/FVB	[22]
Luminal
MMTV-H-Ras	5	MMTV	FVB	[15]
MMTV-Her2/neu	5	MMTV	FVB	[16]
MMTV-c-Myc	5	MMTV	FVB	[17]
MMTV-PyMT	6	MMTV	FVB	[18]
MMTV-Wnt1	4	MMTV	FVB	[19]

MMTV: mouse mammary tumor virus promoter, often expressed in virgin mammary gland epithelium, induced with lactation; often expressed at ectopic sites (for example, lymphoid cells, salivary gland, others). C3(1): 5' flanking region of the C3(1) component of the rat prostate steroid binding protein, expressed in mammary ductal cells and at low levels in other tissues. PyMT: polyoma middle T antigen.

ISSN: 1474-760X