Table 2 The pathways statistically significant in the 3% most increased transcripts in PPARδ agonist-treated cells identified in the multivariate models
P-value | Pathway | Transcripts increased in PPARδ agonist-treated cells mapping to the pathway |
|---|---|---|
6.3e-08 | Glucose regulation of insulin secretion | Cycs, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Ndufb9, Atp5a1, Ndufb5, Gpi1, Tpi1, Pgk1, mt-Co2, Sdhb, Sdhd, mt-Atp6, Cox7b, Ndufb2 |
1.3e-06 | Integration of energy metabolism | Cycs, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Ndufb9, Atp5a1, Cpt2, Ndufb5, Gpi1, Tpi1, Pgk1, mt-Co2, Sdhb, Sdhd, mt-Atp6, Cox7b, Ndufb2 |
1.3e-06 | Diabetes pathways | Hspa8, Cycs, Wdr89, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Myo5a, Ndufb9, Atp5a1, Rps21, Rps3a, Sec11c, Ndufb5, Gpi1, Tpi1, Pgk1, Sdhb, mt-Co2, Dnajb9, Sdhd, mt-Atp6, Cox7b, 2900062L11Rik, Ndufb2 |
8.5e-06 | Electron transport chain | Cycs, Ndufb5, Etfa, mt-Co2, Ndufb10, Sdhb, Sdhd, Ndufb9, Cox7b, Ndufb2 |
7.1e-04 | Citric acid cycle (TCA cycle) | Dld, Sdhb, Sdhd, Mdh2 |
1.4e-03 | Mitochondrial fatty acid β-oxidation of saturated and unsaturated fatty acids | Hadhb, Acadl, Acadvl |
1.6e-03 | Glycolysis | Aldoa, Tpi1, Pgk1, Gpi1 |
4.5e-03 | Metabolism of lipids and lipoproteins | Agpat3, Hadhb, Ppp1cc, Slc27a1, Lass2, Angptl4, Cpt2, Akr1b3, Abcd3, Acadl, Sgpl1, Acaa2, Acadvl, Mod1, Hmgcs2, Adfp |
7.8e-03 | Formation of acetoacetic acid in synthesis of ketone bodies | Hmgcs2, Acaa2 |