Principal component analysis plot based on SNP calls produced from hybrid-selected and non-hybrid-selected samples. The hybrid-selected clinical sample from Senegal (red) clusters with 12 previously sequenced Senegal samples (blue). The hybrid-selected 3D7 samples (red) cluster with the non-hybrid-selected 3D7 sample (yellow). P. falciparum isolates from India (purple) and Thailand (brown) are also represented. PC, principal content.