Advertisement

Advertisement

Table 4 Summary of parameter estimates and significance levels of the multivariate linear regression analysis for the CpG transition/transversion rate ratio (κ)

From: Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content

	Dataset A		Dataset B		Dataset C
	Estimate	-log₁₀(p)	Estimate	-log₁₀(p)	Estimate	-log₁₀(p)
Divergence	0.2574	15.20	0.1450	9.54	0.2093	8.46
Methylation level	0.1666	6.79	0.3116	> 15.70	0.8127	> 15.70
GC content	0.2478	13.98	0.0257	0.57	-0.1815	5.84
Transcription level	-0.1744	7.31	-0.0294	0.69	0.0871	1.77
Female recombination rate	-0.0321	0.48	0.0533	1.60	0.0210	0.25
Male recombination rate	0.0971	2.49	0.0642	2.13	-0.0130	0.14
Explained variance	3.97%		1.73%		17.73%
n^a	5,550		14,165		3,376

Dataset A contains no CpG islands (CGIs) or DNase I hypersensitive sites (DHSs)), dataset B contains DHSs but no CGIs, and dataset C contains both CGIs and DHSs. ^aSample size.

Back to article page