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Table 4 Summary of parameter estimates and significance levels of the multivariate linear regression analysis for the CpG transition/transversion rate ratio (κ)

From: Substitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content

  Dataset A Dataset B Dataset C
  Estimate -log10(p) Estimate -log10(p) Estimate -log10(p)
Divergence 0.2574 15.20 0.1450 9.54 0.2093 8.46
Methylation level 0.1666 6.79 0.3116 > 15.70 0.8127 > 15.70
GC content 0.2478 13.98 0.0257 0.57 -0.1815 5.84
Transcription level -0.1744 7.31 -0.0294 0.69 0.0871 1.77
Female recombination rate -0.0321 0.48 0.0533 1.60 0.0210 0.25
Male recombination rate 0.0971 2.49 0.0642 2.13 -0.0130 0.14
Explained variance 3.97% 1.73% 17.73%
na 5,550 14,165 3,376
  1. Dataset A contains no CpG islands (CGIs) or DNase I hypersensitive sites (DHSs)), dataset B contains DHSs but no CGIs, and dataset C contains both CGIs and DHSs. aSample size.
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Genome Biology

ISSN: 1474-760X

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