Table 2 Top inferred genes for schizophrenia
From: BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation
Number | Gene | Prioritization hypothesis | SZ association studies |
|---|---|---|---|
1 | PRL | Affected by the antipsychotics aripiprazole and risperidone, neuroactive ligand-receptor interaction, associated with autistic disorder | No association studies. Associated with autistic disorder [16] |
2 | ARID4B | Target of mir-20b | No association studies |
3 | HTR1A | Related to HTR2A | Positive association [19] |
4 | DRD2 | Related to DRD3 | Positive association [20] |
5 | DNMT3B | Target of mir-29*, related to COMT, folic acid | Positive association [21] |
6 | DNMT3A | Target of mir-29*, related to COMT, folic acid | No association studies |
7 | FSTL1 | Target of mir-206 | No association studies |
8 | SYN3 | Related to SYN2 | No association found [23] |
9 | MYLIP | Target of mir-20b, involved in CNS development | No association studies |
10 | EFEMP2 | Target of mir-346 | No association studies |
11 | UTRN | Interacts with DISC1, target of mir-206 | No association studies |
12 | OMG | Myelin sheet, interacts with RTN4R, axonogenesis | Weak positive association [22]. Putatively associated with mental retardation [38] |
13 | BACE1 | Target of mir-29*, Alzheimer's disease | No association studies. Schizophrenia-like phenotypes in BACE1-null mice [39] |
14 | HIPK3 | Target of mir-20b | No association studies |
15 | TAC1 | Target of mir-206, axonal and synaptic transmission | No association studies. Down-regulated in psychosis [40] |
16 | ATXN1 | Interacts with ZNF804A and AKT1 | Positive association [18] |
17 | SYN1 | Related to SYN2 | No association studies. Associated with epilepsy [41] |
18 | RTN4IP1 | Interacts with RTN4R, neurite growth | No association studies |
19 | CDKN1A | Interacts with AKT1, target of mir-20b | No association studies |
20 | LINGO1 | Interacts with RTN4R, axonogenesis, CNS development | No association studies. Associated with essential tremor and Parkinson's disease [42] |