Figure 5

Potential models for lncRNA-TARE at P. falciparum chromosome ends. Model 1: PfSip2 binding at SPE2 sites induces lncRNA-TARE transcription and/or vice versa. Model 2: lncRNA-TARE guides multiple copies of PfSip2 to chromosome ends. Model 3: lncRNA-TARE recruits chromatin-remodeling factors to initiate post-S-phase silencing chromatin memory marks at upsB-type var loci. Model 4: lncRNA-TARE facilitates telomeric heterochromatin assembly and/or interacts with telomere-associated proteins. POL II, RNA polymerase II; TXN, transcription factor.