Skip to main content

Advertisement

Table 2 Resources generated from large-scale mouse genetics projects

From: The mouse genetics toolkit: revealing function and mechanism

Resource Web site Description Reference
Australian Phenomics Network http://www.australianphenomics.org.au Provides resources and services for producing, screening and archiving mutant mice  
Canadian Mouse Mutant Repository http://www.cmmr.ca/ Archived ES cells, sperm, ova, embryos, and DNA  
Cancer Models Database http://cancermodels.nci.nih.gov A database of mouse lines that model the genesis, progression or clinical course of human cancers  
Center for Animal Resources and Development http://cardb.cc.kumamoto-u.ac.jp/transgenic A repository of over 1,300 mutant lines  
Centre for Modeling Human Disease http://www.cmhd.ca/databases ENU mutagenesis and gene trap databases  
Collaborative Cross http://mouse.ornl.gov/projects/collabcross.html A resource for the genetic analysis of complex traits [110]
Cre-X-mice http://nagy.mshri.on.ca A Cre-expressing transgenic mouse line database [44]
CreZoo http://bioit.fleming.gr/crezoo A Cre-expressing transgenic mouse line database  
Ensembl http://www.ensembl.org A genome database for mouse and other eukaryotes [111]
European Conditional Mouse Mutagenesis Program http://www.eucomm.org Aims to generate and distribute a collection of 13,000 mutated ES cell lines using conditional approaches [112]
European Mouse Disease Clinic http://www.eumodic.org Aims to generate phenome data on 650 knockout mice generated by the EUCOMM project [82]
European Mouse Mutant Archive http://www.emmanet.org A European repository with over 1,700 mutant strains [113]
European Mouse Phenotyping Resource for Standardized Screens (EMPReSS) http://empress.har.mrc.ac.uk A primary screening platform with over 100 standard operating procedures validated on inbred strains [81]
European Union Mouse Research for Public Health and Industrial Applications http://www.eumorphia.org Novel approaches in phenotyping, mutagenesis and informatics to improve the characterization of mouse models [114]
EuroPhenome http://www.europhenome.org A database to hold phenome data from EMPReSS [115]
Federation of International Mouse Resources http://www.fimre.org Coordinates repositories and resource centers globally [116]
GenomeSpace http://www.genomespace.org A central workspace for genomics tools, including Galaxy, Integrative Genomics Viewer and UCSC Browser  
Heterogeneous Stock Phenotyping Project http://mus.well.ox.ac.uk/mouse/HS A searchable map of QTLs that contribute to variation in over 100 complex traits, using Heterogeneous Stock mice [88]
International Gene Trap Consortium http://www.genetrap.org Information on >380,000 gene-trapped ES cell lines [117]
International Knockout Mouse Consortium http://www.komp.org/ikmc Aims to minimize overlap, share resources, and improve services among the three major knockout projects [79]
Knockout Mouse Project http://www.knockoutmouse.org Aims to target 8,500 genes and make mice available to the community [4]
MouseBook http://www.mousebook.org MRC Harwell's mouse resources; includes a frozen embryo and sperm archive, an ENU screen and DNA archive, and standardized phenotyping procedures [118]
Mouse Genome Database http://www.informatics.jax.org Provides integrated genetic, genomic, and biological data on laboratory mouse strains [119]
Mouse Genomes Project http://www.sanger.ac.uk/resources Raw sequence data, SNPs and assemblies of 17 mouse genomes  
Mouse Phenome Project http://phenome.jax.org A collection of baseline phenotypic data on commonly used inbred mouse strains [83]
Mouse Resources Portal http://www.sanger.ac.uk/mouseportal The Sanger Institute's resources; includes available BACs, gene targeting vectors, ES cells and mutant mouse lines with associated phenotypic data [10]
Mutant Mouse Regional Resource Centers http://www.mmrrc.org A repository of mouse stocks and ES cell lines  
North American Conditional Mouse Mutagenesis project http://www.norcomm.org Aims to target >2,000 genes that have not been previously targeted or trapped [4]
PB Mutagenesis Information Center http://www.idmshanghai.cn/PBmice A database for storing, retrieving and displaying information derived from PB transposon insertions [120]
RIKEN Bioresource Center http://www.brc.riken.jp/lab/animal/en A Japanese repository of live and archived lines