Figure 2

Phenotypic screening of genetically modified mice. Mutant mice available to the community are systematically screened for a range of phenotypes by the Sanger Mouse Genetics Project and the data published online [10]. Some examples of observed phenotypes are shown. (a) An outwardly protruding xiphoid process in Fam73b^{tm1a(KOMP)Wtsi}homozygous mice (top), compared with wild-type controls (bottom). (b) The formation of uroliths (bladder stones) in Clnd16^{tm1a(KOMP)Wtsi}homozygous mice (top), not present in controls (bottom). (c) Underdeveloped molars in Sparc^{tm1a(EUCOMM)Wtsi}homozygous mice (top), compared with control mice (bottom). (d) Abnormal skeletal muscle in Zfp106^{tm1a(KOMP)Wtsi}homozygous mice (top), compared with controls (bottom). (e) A shortened, upturned snout in Smc3^{tm1a(EUCOMM)Wtsi}heterozygous mice. (f) Metacarpophalangeal joint fusion in Dnase1l2^{tm1(KOMP)Wtsi}homozygous mice. (g) Spots of retinal hyperpigmentation in Slc9a8^{tm1a(KOMP)Wtsi}homozygous mice. (h) LacZ reporter gene expression in the adult mammary gland of Myh9^{tm1a(EUCOMM)Wtsi}heterozygous mice.