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Figure 2 | Genome Biology

Figure 2

From: The mouse genetics toolkit: revealing function and mechanism

Figure 2

Phenotypic screening of genetically modified mice. Mutant mice available to the community are systematically screened for a range of phenotypes by the Sanger Mouse Genetics Project and the data published online [10]. Some examples of observed phenotypes are shown. (a) An outwardly protruding xiphoid process in Fam73btm1a(KOMP)Wtsihomozygous mice (top), compared with wild-type controls (bottom). (b) The formation of uroliths (bladder stones) in Clnd16tm1a(KOMP)Wtsihomozygous mice (top), not present in controls (bottom). (c) Underdeveloped molars in Sparctm1a(EUCOMM)Wtsihomozygous mice (top), compared with control mice (bottom). (d) Abnormal skeletal muscle in Zfp106tm1a(KOMP)Wtsihomozygous mice (top), compared with controls (bottom). (e) A shortened, upturned snout in Smc3tm1a(EUCOMM)Wtsiheterozygous mice. (f) Metacarpophalangeal joint fusion in Dnase1l2tm1(KOMP)Wtsihomozygous mice. (g) Spots of retinal hyperpigmentation in Slc9a8tm1a(KOMP)Wtsihomozygous mice. (h) LacZ reporter gene expression in the adult mammary gland of Myh9tm1a(EUCOMM)Wtsiheterozygous mice.

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