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Figure 1 | Genome Biology

Figure 1

From: The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding

Figure 1

DNaseI accessibility and in vivo DNA binding by transcription factors across the eve locus. DNA binding in stage 5 embryos is shown as ChIP-chip scores (blue) for 675-bp windows that fall above a 1% FDR threshold for 21 sequence-specific transcription factors, TFIIB and the transcriptionally active form of RNA polymerase II (POLII). The sequence-specific factors are grouped into three major regulatory classes that regulate patterning along the Dorsal-Ventral axis of the embryo (D-V), initiate patterning along the Anterior-Posterior axis (Early A-P), or establish later pair rule patterns along the Anterior-Posterior axis (Pair rule A-P). DNaseI accessibility at stage 5 is shown for 75-bp windows of sequence tag density (red) along with the locations of accessible regions above the 5% FDR threshold (black bars). At the bottom, the locations of major RNA transcripts are shown (grey) as well as the autoregulatory CRM (Auto) and the four stripe initiation CRMs (S3/7, S2, S4/6 and S1/5) (green). Nucleotide coordinates in the genome are given in base pairs.

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