Figure 1From: The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor bindingDNaseI accessibility and in vivo DNA binding by transcription factors across the eve locus. DNA binding in stage 5 embryos is shown as ChIP-chip scores (blue) for 675-bp windows that fall above a 1% FDR threshold for 21 sequence-specific transcription factors, TFIIB and the transcriptionally active form of RNA polymerase II (POLII). The sequence-specific factors are grouped into three major regulatory classes that regulate patterning along the Dorsal-Ventral axis of the embryo (D-V), initiate patterning along the Anterior-Posterior axis (Early A-P), or establish later pair rule patterns along the Anterior-Posterior axis (Pair rule A-P). DNaseI accessibility at stage 5 is shown for 75-bp windows of sequence tag density (red) along with the locations of accessible regions above the 5% FDR threshold (black bars). At the bottom, the locations of major RNA transcripts are shown (grey) as well as the autoregulatory CRM (Auto) and the four stripe initiation CRMs (S3/7, S2, S4/6 and S1/5) (green). Nucleotide coordinates in the genome are given in base pairs.Back to article page