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Table 6 Concentration of NAD, NADH, NADP, and NADPH

From: Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidisand human cells

  Control 0.16 μM IQ-143 1.25 μM IQ-143
  Mean (μg/ml) SD Mean (μg/ml) SD % of control Mean (μg/ml) SD % of control
NAD 42.19 2.44 35.68** 0.92 84.57 27.89** 0.95 66.11
NADH 3.71 0.31 2.63** 0.28 70.89 1.95** 0.21 52.56
NADP 3.47 0.06 3.24** 0.05 93.37 2.42** 0.05 69.74
NADPH 2.87 0.12 2.25** 0.02 78.40 5.56** 0.22 193.73
  1. Direct measurement of NAD, NADH, NADP, and NADPH concentrations in S. aureus (in μg/ml and percentage of control value depending on the applied IQ-143 concentration). Statistically significant differences are indicated (*P < 0.05,**P < 0.01). SD, standard deviation.