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Table 4 Effects of IQ-143 on diverse enzymes of oxidative phosphorylation and energy and nucleotide metabolism of S. aureus USA300 and S. epidermidis RP62A

From: Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidisand human cells

 

Concentration of IQ-143 (μM)b

Enzymea

0.00

0.16

1.25

S. aureus USA300

   

   OP_complex1

0.0396

0.0260

0.0310

   OP_complex2

0.0396

0.0260

0.0310

   [OP_complex3]

0.0791

0.0520

0.0619

   OP_complex4

0.0396

0.0260

0.0310

   OP_complex5

0.0214

0.0109

0.0031

   PurM_DNA-directed-RNA-polymerase_ATP

0.0791

0.0000

0.0000

   PurM_DNA-directed-RNA-polymerase_CTP

0.0396

0.0260

0.0310

   PurM_DNA-directed-RNA-polymerase_GTP

0.0396

0.0260

0.0310

   PurM_DNA-directed-RNA-polymerase_UTP

0.0285

0.0229

0.0285

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dATP]

0.0396

0.0260

0.0121

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dCTP]

0.0396

0.0260

0.0310

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dGTP]

0.0396

0.0260

0.0310

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dTTP]

0.0396

0.0260

0.0310

   [SERP0841-PurM_PNPase_ADP]

0.0791

0.0520

0.0619

   [SERP0841-PurM_PNPase_GDP]

0.0265

0.0174

0.0207

   Glyc_glyceraldehyde-3-P-dehydrogenase_NAD+

0.1582

0.1040

0.1238

   Glyc_glyceraldehyde-3-P-dehydrogenase_NADP+

0.0601

0.2102

0.1251

   TCA_pyruvate_dehydrogenase

0.0396

0.0260

0.0310

S. epidermidis RP62A

   

   OP_complex1

0.0201

0.0201

0.0126

   OP_complex2

0.0161

0.0161

0.0050

   [OP_complex3]

0.0361

0.0361

0.0175

   OP_complex4

0.0334

0.0334

0.0292

   OP_complex5

0.0669

0.0669

0.0585

   PurM_DNA-directed-RNA-polymerase_CTP

0.0334

0.0334

0.0292

   PurM_DNA-directed-RNA-polymerase_GTP

0.0120

0.0120

0.0436

   PurM_DNA-directed-RNA-polymerase_UTP

0.0334

0.0334

0.0292

   PurM_DNA-directed-RNA-polymerase_ATP

0.0334

0.0334

0.0292

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dATP]

0.0334

0.0334

0.0766

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dCTP]

0.0224

0.0224

0.0196

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dGTP]

0.0334

0.0334

0.0292

   [SERP0831-PurM_DNA-directed-DNA-polymerase_dTTP]

0.0468

0.0468

0.0409

   [SERP0841-PurM_PNPase_ADP]

0.0669

0.0669

0.0585

   [SERP0841-PurM_PNPase_GDP]

0.0120

0.0120

0.0050

   Glyc_glyceraldehyde-3-P-dehydrogenase_NAD+

0.0669

0.0669

0.0585

   Glyc_glyceraldehyde-3-P-dehydrogenase_NADP+

0.0241

0.0241

0.0228

   TCA_pyruvate_dehydrogenase

0.0161

0.0161

0.0468

  1. This table lists the effects of three different concentrations of IQ-143 on the activity of diverse enzymes of the described pathways and reactions in S. aureus USA300 and S. epidermidis RP62A. aEnzymes in brackets were also detected by their gene expression change in S. epidermidis RP62A. bConcentrations tested were no IQ-143, 0.16 μM IQ-143 and 1.25 μM IQ-143. PurM, purine metabolism.