Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidisand human cells

Table 3 Identification of stress response mechanisms in S. epidermidis RP62A1¹

	Hit
Query	Family	Description	Entry type	Clan	Bit score	E-value
SERP2244	PGA_cap	Bacterial capsule synthesis protein PGA_cap	Domain	CL0163	233.2	2.3e-69
SERP1998	AHSA1	Activator of Hsp90 ATPase homolog 1-like protein	Family	CL0209	67.8	6.9e-19

This table provides BLAST [48] results of the two putative stress response mechanisms of S. epidermidis RP62A we detected by iterative sequence search. PGA_cap encodes a poly-gamma-glutamate capsule, which could improve the survivability under salt stress. AHSA1 encodes an activator of the Hsp90 ATPase homolog 1-like protein, which results in an increase of efficiency of the Hsp90 function and thus leads to higher survivability under stress conditions.

ISSN: 1474-760X