Changes in extreme modes in S. aureus USA300 with three different concentrations of IQ-143. Red shading indicates lower activities after IQ-143 administration, green shading indicates higher activities, and 'sau' denotes S. aureus. Each row displays six extreme modes (continuously numbered from 1 to 198); numbers given in the fields are the activities for each mode under different concentrations of IQ-143. Also given are the pathways in which the modes are involved. Abbreviations: A, amino acids; E, energy metabolism; F, fatty acids; N, nucleotide metabolism; O, oxidative phosphorylation; T, transporters. All details are also shown in Additional file 1 (Tables S7, S8, and S9; key changes in Tables S18 and S19).