Figure 2

Predicted structural topology of TRP channels. (a) All channels contain six transmembrane segments (S1 to S6) with a putative pore region (P) between S5 and S6. Amino and carboxyl termini are variable in length and contain different sets of domains. (b) Distribution of domains in selected human TRP channels [103]. The number and composition of domains vary between different TRP channels and are only partially preserved within members of the same subfamily. aa, amino acids; CaM, calmodulin; EF hand, helix-loop-helix Ca²⁺ binding motif; PH, pleckstrin homology domain; ER, endoplasmic reticulum; NUDIX domain, nucleoside diphosphate linked moiety X-type motif.