Figure 5From: Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in seraTraSH ratios of lipopolysaccaride synthesis gene groups. (a) Average TraSH ratios from the initial selection for genes involved in lipopolysaccaride (LPS) synthesis. (b) Average competitive indices (the change in TraSH ratios) following sequential culturing on Columbia Agar Base (CAB; clear bars), serum (lined bars) and minimal media (MM) agar (filled bars) for genes involved in LPS synthesis. Values are the average of five biological replicates (three for sera). The pathway for LPS synthesis [58] is shown on the left. KDO, 2-keto-3-deoxyoctonoic acid.Back to article page