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Figure 4 | Genome Biology

Figure 4

From: Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera

Figure 4

TraSH ratios of functional gene groups. (a) Average TraSH ratios for functional gene groups from the initial selection. (b) Average competitive indices (the change in TraSH ratios) for functional gene groups following sequential culturing on Columbia Agar Base (CBA; clear bars), serum (lined bars) and minimal media (MM) agar (filled bars). All values are the average of five biological replicates (three for sera). Cell envelope genes include those involved in peptidoglycan, capsule and lipopolysaccaride (LPS) synthesis as well as pili; cell processes includes genes associated with cell division, pathology, and so on; intermediate metabolism includes phosphate and sulfur metabolism; energy metabolism includes glycolysis, the pentose phosphate pathway, the tricarboxylic acid cycle, fermentation, electron transport and ATP synthesis; mobile elements includes prophage, plasmid and transposon associated genes; other categories are self-explanatory.

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