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Table 3 Genes mutated in at least two S.pneumoniae penicillin resistant mutants

From: Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease

 

S. pneumoniaestrains

Locus name

R6M1

R6M2

1974M1

1974M2

PBP1a

G544R

W411*

E248*

E158*

PBP2x

R384G,V518I, Q552E

Q281P, A369V, R384G, R426C, V518I

F388L, Q552E, V573L, V587L, G601V

A507V, P535L, Q552E

PBP2b

D415E, G665D

A395V, G435S, T451A

G435S, T451A

T431D, T451A, L492F, Q633E

Spr1178

Q28*

Q28*

Q28*

Q28*

Spr1254

G167S

T205I

WT

WT

Spr1888

T728I

Q326*

WT

WT

  1. Mutations are shown as amino acid changes with their corresponding position in the protein. Asterisks indicate nonsense mutations. Mutations that are common in at least two strains are in bold.
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Genome Biology

ISSN: 1474-760X

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