Figure 5

Relationship between ribosomal density, local tAI, folding, and charge in single genes of S. cerevisiae. (a) Histogram of the positions of the tAI bottleneck (the region with the slowest tAI). (b) Histogram of the positions of the folding energy bottleneck (the region with the strongest folding energy). (c) Histogram of the positions of the charge bottleneck (the region with the highest positive charge). (d) Histogram of the positions of the region with the highest ribosomal density. (e) Histogram of the distance between the composite bottleneck (based on the regressor that weighs the tAI, charge, and folding energy; Materials and methods) and the region with the highest ribosomal density positions. (f) Histogram of the distance between the composite bottleneck (based on the ribosome movement model; Materials and methods) and the region with the highest ribosomal density positions. Similar results were observed when we performed cross-validations.