Figure 1

Mean genomic profiles of three features of the coding sequences. The mean genomic profiles of ribosome density, tAI, folding energy, and amino acid charge in S. cerevisiae and E. coli when aligning all the genes to their beginning (upper panels; Materials and methods) or end (lower panels; Materials and methods). In the case of the beginning profile, each panel also includes the region of the ramp (Materials and methods), a P-value corresponding to a comparison of the ramp to the rest of the profile (black; Materials and methods), and a P-value corresponding to a control for amino acid content (brown; Materials and methods).