TY - JOUR AU - Kloosterman, Wigard P. AU - Hoogstraat, Marlous AU - Paling, Oscar AU - Tavakoli-Yaraki, Masoumeh AU - Renkens, Ivo AU - Vermaat, Joost S. AU - van Roosmalen, Markus J. AU - van Lieshout, Stef AU - Nijman, Isaac J. AU - Roessingh, Wijnand AU - van 't Slot, Ruben AU - van de Belt, José AU - Guryev, Victor AU - Koudijs, Marco AU - Voest, Emile AU - Cuppen, Edwin PY - 2011 DA - 2011/10/19 TI - Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer JO - Genome Biology SP - R103 VL - 12 IS - 10 AB - Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently described to occur in a small percentage of tumors. The significance of these clusters for tumor development or metastatic spread is largely unclear. SN - 1474-760X UR - https://doi.org/10.1186/gb-2011-12-10-r103 DO - 10.1186/gb-2011-12-10-r103 ID - Kloosterman2011 ER -