From: The rhomboid protease family: a decade of progress on function and mechanism
Rhomboid | Organism | Substrate | Function | References |
---|---|---|---|---|
Rho-1 | Drosophila | Spitz, Keren | EGFR signaling (embryo, most developing tissues, adult) | [8–16, 89] |
Rho-2/Stet | Drosophila | Gurken,? | EGFR signaling in oocyte, germline | [89, 90] |
Rho-3/Ru | Drosophila | Spitz, Keren | EGFR signaling in embryo, eye disc | [12, 89, 91] |
Rho-4 | Drosophila | Spitz, Keren? | EGFR signaling? | [89] |
Rho-7 | Drosophila | DmOpa1-like DmPINK1 | Mitochondrial fusion, mitophagy | [30, 55] |
CeROM1 | C. elegans | LIN-3L | Amplifying EGFR signaling (vulva) | [47] |
AarA | P. stuartii | TatA | Activating twin-arginine translocon, quorum sensing | [20, 17, 61, 62, 66] |
GlpG | E. coli | ? | ? | [17–20, 34–36, 77, 78, 83–85, 88] |
HiGlpG | H. influenzae | ? | ? | [37, 81] |
YqgP | Bacillus subtilis | ? | ? | [17, 18, 20] |
PA3086 | Pseudomonas aeruginosa | ? | ? | [17, 18, 20] |
AqRho | Aquifex aeolicus | ? | ? | [17, 20] |
Pcp1 | Saccharomyces cerevisiae | Mgm1, Ccp1 | Mitochondrial membrane fusion, pre-sequence removal | [28, 52–54] |
PARL | Homo sapiens Mus musculus | PINK1, others | Downregulating mitophagy, crista remodeling, anti-apoptosis | [28, 29, 56–60] |
AtRBL2 | Arabidopsis thaliana | ? | ? | [23] |
RHBDL2 | H. sapiens | TM, EphrinB1,2,3, EGF | Blood clotting? Cell migration? Cancer? | [24, 48, 87] |
PfROM4 | P. falciparum | EBA175, TRAP, other adhesins | Invasion | [26, 69] |
PfROM1 | Plasmodium sp. | AMA1? | Invasion? Growth | [26, 69, 70] |
TgROM1 | Toxoplasma gondii | ? | Growth | [25, 40, 68, 75] |
TgROM2 | T. gondii | ? | ? | [25, 40, 68] |
TgROM3 | T. gondii | ? | ? | [25, 68] |
TgROM4 | Toxoplasma gondii | AMA1, MIC2, MIC6 | Invasion | [25, 68, 71, 72] |
TgROM5 | Toxoplasma gondii | AMA1, MIC2, MIC6 | Invasion | [25, 26] |
EhROM1 | Entamoeba histolytica | Lectins | Phagocytosis, immune evasion | [73, 74] |