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Table 1 Known rhomboid protease substrates and functions across evolution

From: The rhomboid protease family: a decade of progress on function and mechanism

Rhomboid Organism Substrate Function References
Rho-1 Drosophila Spitz, Keren EGFR signaling (embryo, most developing tissues, adult) [816, 89]
Rho-2/Stet Drosophila Gurken,? EGFR signaling in oocyte, germline [89, 90]
Rho-3/Ru Drosophila Spitz, Keren EGFR signaling in embryo, eye disc [12, 89, 91]
Rho-4 Drosophila Spitz, Keren? EGFR signaling? [89]
Rho-7 Drosophila DmOpa1-like DmPINK1 Mitochondrial fusion, mitophagy [30, 55]
CeROM1 C. elegans LIN-3L Amplifying EGFR signaling (vulva) [47]
AarA P. stuartii TatA Activating twin-arginine translocon, quorum sensing [20, 17, 61, 62, 66]
GlpG E. coli ? ? [1720, 3436, 77, 78, 8385, 88]
HiGlpG H. influenzae ? ? [37, 81]
YqgP Bacillus subtilis ? ? [17, 18, 20]
PA3086 Pseudomonas aeruginosa ? ? [17, 18, 20]
AqRho Aquifex aeolicus ? ? [17, 20]
Pcp1 Saccharomyces cerevisiae Mgm1, Ccp1 Mitochondrial membrane fusion, pre-sequence removal [28, 5254]
PARL Homo sapiens Mus musculus PINK1, others Downregulating mitophagy, crista remodeling, anti-apoptosis [28, 29, 5660]
AtRBL2 Arabidopsis thaliana ? ? [23]
RHBDL2 H. sapiens TM, EphrinB1,2,3, EGF Blood clotting? Cell migration? Cancer? [24, 48, 87]
PfROM4 P. falciparum EBA175, TRAP, other adhesins Invasion [26, 69]
PfROM1 Plasmodium sp. AMA1? Invasion? Growth [26, 69, 70]
TgROM1 Toxoplasma gondii ? Growth [25, 40, 68, 75]
TgROM2 T. gondii ? ? [25, 40, 68]
TgROM3 T. gondii ? ? [25, 68]
TgROM4 Toxoplasma gondii AMA1, MIC2, MIC6 Invasion [25, 68, 71, 72]
TgROM5 Toxoplasma gondii AMA1, MIC2, MIC6 Invasion [25, 26]
EhROM1 Entamoeba histolytica Lectins Phagocytosis, immune evasion [73, 74]
  1. Only those rhomboid proteases whose proteolytic activity has been detected are included in the table. A question mark '?' denotes unknown function. EGFR, epidermal growth factor receptor.