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Table 1 Results of the statistical analysis with respect to the unknown dataset

From: Coding potential of the products of alternative splicing in human

 

Coverage

TP

TN

FP

FN

Accuracy

Sensitivity

Specificity

AS

0.14

79

31

48

1

0.69

0.99

0.39

St

0.26

134

76

69

13

0.72

0.91

0.52

Pfam

0.81

480

165

227

23

0.72

0.95

0.41

AS U St

0.35

175

101

99

14

0.71

0.93

0.50

St U Pfam

0.89

490

203

257

35

0.71

0.93

0.44

AS U Pfam

0.85

485

186

250

24

0.71

0.95

0.43

AS U St U Pfam

0.92

494

221

272

36

0.70

0.93

0.45

AS ∩ St

0.06

38

6

18

0

0.71

1.00

0.25

St ∩ Pfam

0.18

124

38

39

1

0.80

0.99

0.49

AS ∩ Pfam

0.10

74

10

25

0

0.77

1.00

0.28

AS ∩ St ∩ Pfam

0.05

37

3

10

0

0.80

1.00

0.23

  1. Coverage, accuracy, sensitivity and specificity of the different strategies and their combinations (U = union and ∩ = intersection) with respect to the unknown dataset. AS, preservation of active sites; Pfam, completeness of Pfam domains; St, structural plausibility. The definition of the other parameters is reported in Materials and methods. FN, false negative; FP, false positive; TN, true negative; TP, true positive.