Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

Table 2 Putative PKS and NRPS genes of A. benhamiae, T. verrucosum, and C. immitis

Type	LocusLink Arthroderma benhamiae	LocusLink Trichophyton verrucosum	LocusLink Coccidioides immitis	Domain architecture
PKSs
Non-reducing	ARB_00538	TRV_00386	-	KS-AT-ACP
	ARB_03291	TRV_02519	CIMG_13102	KS-AT-ACP-ME^a
	-	-	CIMG_05571	KS-AT-ACP
	-	-	CIMG_04689	KS-AT-ACP-ME
	-	-	CIMG_03162	KS-AT-ACP
	ARB_07994	TRV_04611	CIMG_08569	KS-AT-ACP-ACP-TE
	-	-	CIMG_08564	AT-KS-ACP-TE
Reducing	ARB_01525	TRV_04236	CIMG_13632	KS-AT-ME-ER-KR-ACP
	ARB_05854	TRV_06867	-	KS-AT-KR-ACP^b
	ARB_06393	TRV_01071	-	KS-AT-ME-ER-KR-ACP
	ARB_05333	TRV_06912	CIMG_02398	KS-AT-DH-MT-ER-KR-ACP
	ARB_07933	TRV_04104	-	KS-AT-ME-ER-KR-ACP
	ARB_07966	TRV_04285	-	KS-AT-ME-KR-ACP
	-	-	CIMG_05569	KS-AT-DH-ER-KR-ACP
	-	-	CIMG_03014	KS-AT-DH-ER-KR-ACP
	ARB_00195	TRV_05651	CIMG_07298	A-T-C-T-C
	-	-	CIMG_01429	A-T-C-T
	ARB_01698	TRV_01735	CIMG_09750	C-A-T-C-A-T-C-A-T-C-A-T-C-A-T-C-T-C-T
	ARB_02149	-	-	C-A-T-C-A-T-C-A-T-C-A-T-C^c
	ARB_02226	TRV_00553	-	A-T-C-A-T-C-A-T-C
	ARB_02570	TRV_5508	-	A-T-C
	ARB_02750	TRV_06186	-	A-T-C-A-T-C-A-T-C-A-T-C-A-T-C-T
	ARB_03095	TRV_06056	-	T-C-A-T-C/T-C-A
NRPSs	ARB_03768	TRV_07570	-	A-C-A-T-C-A-T
	ARB_04984	TRV_06313	CIMG_01861	A-T-C-A-T-C
	ARB_05131	TRV_07837	-	A-T-C-A-T-C-A-T
	ARB_05579	TRV_06828	-	T-C-A-T-C-A-T
	ARB_06786	TRV_05681	-	A-T-C
	ARB_07686	TRV_05452	CIMG_00941	A-T-C-A-T-C-T-C-A-T-C-T-C-T-C
	ARB_07850	TRV_01776	-	A-T-C/A-T-C-A-T
	ARB_07862	TRV_04720	-	A-T-C-A-T-C-T
	ARB_07534	TRV_00508	-	KS-AT-DH-ER-KR-ACP-C-A-T
PKS/NRPS hybrids	ARB_02973	TRV_03721	CIMG_06629	KS-AT-ME-KR-ACP-C-A-T
	ARB_07844	TRV_05146	-	A-T-KS-AT-KR-ACP-TE

^aPotential citrinin-like product; similar to pksCT BAD44749.1. ^bProduct 6-methyl-salicylic acid; similar to 6-MSA synthase CAA39295.1. ^cUnique for A. benhamiae. A, adenylation domain; ACP(PP), acyl carrier protein, or phosphopantetheine domain; AT, acetyltransferase domain; C, condensation domain; DH, dehydratase domain; E, epimerization domain; ER, enoyl reductase domain; KR, ketoacyl reductase domain; KS, beta-ketoacyl synthase domain; ME, methyltransferase domain; T, thiolation domain; TE, thioesterase domain.

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