Figure 5
Granzyme E alleles are associated with su sceptibility. (a) Log2 expression of Gzme in skin, papillomas, and carcinomas. Gzme mRNA is not detected in normal skin, and its level of expression is highest in papillomas from mice that are relatively resistant to papilloma development. Papillomas from resistant animals are plotted as blue circles, susceptible animals as red circles. (b) Expression of Gzme in papillomas and carcinomas is under germline genetic control. LOD plot for Gzme carcinoma eQTL significance on chromosome 14.