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Figure 2 | Genome Biology

Figure 2

From: Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility

Figure 2

DNA copy number changes reduce germline influence. (a) Percentage of carcinomas with alterations across the mouse genome; amplifications (blue) plotted above zero, deletions (red) below zero. Chromosome 7 is most frequently amplified. (b) Counts of eQTL in skin on autosomal chromosomes (grey bars) compared to percentage of those eQTL conserved in carcinomas (black bars). Left-side scale indicates eQTL counts, right-side scale indicates conservation percentage. Conservation percentage is lowest on chromosome 7. (c) Amplification of aCGH probe MouseArray1M2_K17, at chromosome 7, 144.5 Mb, is significantly associated with increased expression of Cyclin D1 in carcinomas compared to matched normal skin. Amplification of this region of distal chromosome 7 accounts for loss of eQTL for Cyclin D1 and other genes in this region.

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