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Table 3 Regulating the regulators

From: Genome-wide analysis of mRNA decay patterns during early Drosophiladevelopment

Process or pathway

mRNA decay targets in embryos

miRNA pathway

Dcr-1

piRNA pathway

aub, piwi

RNAi/siRNA pathway

Dcr-2, r2r2, vig, spn-E, armi, Fmr1

Nonsense mediated mRNA decay

Upf1, btz, Smg6

5' -to-3' mRNA decay

pcm (Xrn1), Dhh1

3' -to-5' mRNA decay

Rrp4, Rrp42, Rrp45

Deadenylation

twin (ccr4), pop2, Not1

Decapping

Dcp2

  1. Transcripts of key proteins in mRNA decay pathways are degraded in early fly embryos. miRNA, microRNA; piRNA, piwi-interacting RNA; RNAi, RNA interference; siRNA, small interfering RNA.