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Table 1 Relating mRNA decay to gene function

From: Genome-wide analysis of mRNA decay patterns during early Drosophiladevelopment

GO term

P-value

Cellular component

 

   Replication fork

2.38E-06

   Nuclear chromosome

5.18E-05

   Nuclear chromosome part

6.91E-05

   Chromosome

4.95E-04

   Microtubule organizing centre part

1.78E-03

   Replisome

1.96E-03

   Nuclear replisome

1.96E-03

   Nuclear replication fork

1.96E-03

   Endoplasmic reticulum membrane

2.77E-03

   Nuclear envelope-endoplasmic reticulum network

3.35E-03

   Endomembrane system

4.43E-03

   Rough endoplasmic reticulum membrane

9.11E-03

Gene function

 

   Rough endoplasmic reticulum membrane

9.11E-03

   Transferase activity

4.13E-11

   Lipid binding

4.88E-06

   Zinc ion binding

1.37E-05

   Cofactor binding

2.37E-05

   Nucleoside-triphosphatase activity

3.97E-05

   DNA-dependent ATPase activity

4.66E-05

   Pyrophosphatase activity

8.22E-05

   Metal ion binding

8.64E-05

   DNA-directed DNA polymerase activity

1.09E-04

   Cation binding

1.14E-04

   Ion binding

1.18E-04

   Aminoacyl-tRNA ligase activity

1.18E-04

   Ligase activity, forming aminoacyl-tRNA and related compounds

1.18E-04

   Ligase activity, forming carbon-oxygen bonds

1.18E-04

   Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

1.21E-04

   Transferase activity, transferring phosphorus-containing groups

2.20E-04

   Hydrolase activity, acting on acid anhydrides

2.40E-04

   DNA polymerase activity

2.94E-04

   DNA binding

3.42E-04

   Ligase activity

6.84E-04

   Transition metal ion binding

1.28E-03

   ATPase activity

2.13E-03

   Nucleotidyltransferase activity

3.77E-03

   Phosphoinositide binding

6.49E-03

   DNA helicase activity

6.87E-03

   Coenzyme binding

7.56E-03

Biological process

 

   DNA metabolic process

3.34E-13

   Cellular ketone metabolic process

1.19E-11

   Oxoacid metabolic process

3.59E-11

   Organic acid metabolic process

3.59E-11

   Carboxylic acid metabolic process

3.59E-11

   DNA replication

7.52E-10

   Macromolecule localization

8.71E-07

   Cellular localization

1.35E-06

   Cellular response to stress

1.44E-06

   Cellular response to stimulus

2.09E-06

   Cellular amine metabolic process

3.25E-06

   Cellular amino acid metabolic process

3.25E-06

   Cellular macromolecule localization

8.09E-06

   Cellular response to DNA damage stimulus

1.00E-05

   Response to DNA damage stimulus

2.21E-05

   Response to stress

7.37E-05

   Cellular carbohydrate metabolic process

1.20E-04

   DNA repair

1.43E-04

   Cofactor metabolic process

2.09E-04

   Cellular amino acid and derivative metabolic process

2.14E-04

   Localization

2.24E-04

   Establishment of protein localization

2.52E-04

   Protein transport

3.45E-04

   Regulation of cellular component organization

3.67E-04

   Cellular catabolic process

3.77E-04

   Establishment of localization

8.90E-04

   tRNA aminoacylation for protein translation

1.69E-03

   tRNA aminoacylation

1.69E-03

   Regulation of cell cycle

1.69E-03

   Amino acid activation

2.11E-03

   Organelle fission

2.67E-03

   Establishment of localization in cell

3.75E-03

   DNA-dependent DNA replication

3.84E-03

   ncRNA metabolic process

5.46E-03

   Pyruvate metabolic process

5.86E-03

   Transport

7.27E-03

   Monocarboxylic acid metabolic process

8.38E-03

   Anatomical structure formation

8.67E-03

  1. Gene ontology (GO) analysis for the top 1,000 unstable mRNAs in early embryos using GO::TermFinder. We report significant GO terms and associated P-values unique to unstable mRNAs. Cutoff P-value = 0.01.