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Figure 2 | Genome Biology

Figure 2

From: A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

Figure 2

Illustrating the statistical model. (a) The tumor sample consists of DNA contributions from an unknown number of clones (here, we illustrate three clones) and normal cells in different proportions. Each clone has its own set of tumor genotypes which are derived from the normal genotypes by the loss or duplication of alleles. (b) Our statistical model assumes that, at each locus, there exists a normal and a common tumor genotype. OncoSNP estimates the normal and common tumor genotype and the proportion of the sample explained by each genotype from the SNP data. The situation depicted at SNP 5 involves clones with different tumor genotypes - this is not considered under our model.

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