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Figure 3 | Genome Biology

Figure 3

From: Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

Figure 3

Role of conservation in target prediction. (a) Empirical cumulative distribution of log expression changes of genes with single canonical sites for miR-15a, filtered by increasing conservation thresholds. Distributions of more conserved sites display a subtle shift towards negative values indicating a slight increase in downregulation of target genes. (b) Detection rate of miR-15a targets defined as genes with a single canonical miR-15a site that are in the top 5% most downregulated genes (443 genes). Under increasing conservation thresholds, the detection rate of the most downregulated miR-15a targets drops substantially, showing loss of detection of genes with effective but non-conserved sites. Detection rates were scaled by the maximum number of miR-15a targets identified in the top 5% most downregulated genes without conservation filtering (red line).

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