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Figure 6 | Genome Biology

Figure 6

From: Intronic motif pairs cooperate across exons to promote pre-mRNA splicing

Figure 6

Co-occurring pairs are conserved in evolution. (a) Conservation of motif pairing in human and macaque. Conservation is defined as the proportion of orthologous constitutive exon pairs in which the upstream motif of a pair has been conserved given the conservation of a downstream motif (filled bars). The control (open bars) scored the conservation of non-co-occurring motif pairs (see text). (b) As (a), but in the other direction, scoring the conservation of the downstream motif given the conservation of the upstream motif. (c) Lower SNP density in intronic motifs of co-occurring pairs around constitutive exons. (d) Lower SNP density in intronic motifs of co-occurring pairs around alternative exons. The proportions of motifs containing SNPs were examined for the same set of motifs either when part of a co-occurring pair or when alone. Error bars are the standard error of the mean. *P < 0.05; **P < 0.01; ***P < 10-7; ****P < 10-13.

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