Phylogenetic tree of the cadherin family, showing all members of the novel oomycete subfamily (green) and their relationships to representative metazoan and choanoflagellate cadherins. The major clades of cadherins  are colored: C-1 (blue), Cr-1a and Cr-1b (red), C-2 (purple), and Cr-3 (orange). Most of the oomycete cadherins fall within a fairly distinct subfamily (green), though this subfamily has many long branches and also includes some cadherins from the choanoflagellate M. brevicollis (labeled starting with 'MB') that are also highly diverged from other cadherins. Reliable branches (bootstrap > 50%) are labeled with a circle. All full-length oomycete cadherin domains are shown, from P. ultimum (labeled starting with 'Pu' and ending with the number of the repeat relative to the amino terminus), Ph. infestans (labeled starting with 'Pi'), Ph. sojae (Ps) and Ph. ramorum (Pr). Other cadherins are from the human genome ('Hs') unless labeled starting with 'Dm' (Drosophila melanogaster) or 'Ce' (Caenorhabditis elegans). The figure was drawn using the iTOL tool .