Quality assessment of our predictions. (a) Functional classification of predicted targets. Functional classes are based on the MIPS functional catalog, but sometimes we merged several classes, and they were adapted to make them virtually non-overlapping. DNA RRR, DNA replication, recombination and repair; SPB, spindle pole body. Thirteen MBF and 14 SBF targets were of unknown function; they are not considered in the percent calculation. (b) Comparison of the predictive power of our classification with those of Beyer et al.  and Holloway et al. . MCC was used to assess the ability of each classification to detect true regulatory TF-target associations in the case of divergently transcribed genes for which binding had been reported (Gao et al. ; Chen et al. ).