Figure 5From: Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damagePercentage of normal karyoplates after ICSI with sperm from mice with NPY deficiency. Sperm from males with severe NPYq deficiency (9/10NPYq- and NPYq-2) but not males with moderate NPYq gene loss (2/3NPYq) led to increased incidence of abnormal karyoplates compared to respective sperm types from their appropriate controls, as revealed by Fisher's exact probability test. Statistical significance: b = P < 0.01; d = P < 0.0001 versus matching sperm type in control. Two males were used per genotype; four sperm groups (epididymal, frozen epididymal, testicular and frozen testicular) were examined per male; approximately 15 (15.88 ± 6.52) oocytes were scored per group per male.Back to article page