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Table 2 Pathway data sources in the functional interaction network

From: A human functional protein interaction network and its application to cancer data analysis

Data source Proteins SwissProt proteins (coverage) Interactions Reference
Reactome 4,490 3,863 (19%) 74,869 [23]
Panther 1,912 1,355 (7%) 33,425 [60]
CellMap 567 567 (3%) 1,195 [61]
NCI Nature 1,492 1,486 (7%) 10,845 [62]
NCI BioCarta 1,137 1,136 (6%) 6,695 [62]
KEGG 2,497 2,261 (11%) 13,934 [63]
TRED 1,167 1,166 (6%) 3,030 [64]
  1. SwissProt coverages were calculated as described in Table 1. NCI Pathway Interaction Database has two divisions: batch-imported pathways from BioCarta [83] and pathways hand-curated by NCI Nature pathway curators. We represent these two divisions separately. TRED is a transcription factor/target database. We have imported the human curated part of transcription factor-target interactions from this database for our network.