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Figure 6 | Genome Biology

Figure 6

From: Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells

Figure 6

TFIIB/NC2 ratio reflects transcription start site patterns. (a) Start site patterns in TFIIB- versus NC2-dominated genes. Pie charts show the fraction of promoters for which a distinct TSS pattern could be assigned. Individual regions displaying single peak or dominant peak shape were classified as focused TSSs, and those displaying broad or multimodal peak shape were classified as dispersed TSSs (classification following [43]). Examples of genes with focused and dispersed TSS patterns (taken from [44]) are shown. (b) TFIIB profiles (green) and NC2 profiles (red) at promoters of TFIIB-dominated genes (left), or NC2-dominated genes (right). For each profile the relative fraction of high-score (upper 5th percentile) probes mapping to distinct 10 bp bins around the aligned TSS is plotted, with score maxima arbitrarily set to 1.

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