Figure 3
From: Genomic features defining exonic variants that modulate splicing
Distribution of specific types of NI-ESR changes for SAVs and hSNPs compared to neutral expectation. The tilde symbol (~) signifies an alteration where the hexamer is designated an ESE, neutral or ESS in both the wild-type and variant sequences. The arrow represents the direction of the change as a consequence of the change between wild type and variant hexamer. The neutral expected distribution reflects the underlying probability of each type of change given the ESE/ESS distribution among NI hexamers and the genome-wide nucleotide substitution bias in coding regions.