Figure 4

Inference of increased gene content through evolutionary time for the lineage leading to the human genome. The analysis is performed with versions 39, 40, and 41 of the ENSEMBL database as well as with the human phylome (PhylomeDB, as of December 2008). The inclusion of low-coverage genomes (appearing for the first time in ENSEMBL v41 gene trees) generates an artifactual peak of gene gains at the eutherian nodes. Note that the first four low-coverage genomes (rabbit, elephant, tenrec, and armadillo) were added in the sequence database, but not the gene trees, of version 40.