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Table 3 Assigning putative functions to longevity genes

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

Gene

Gene Ontology biological process

P-value

rpl-4

Cellular macromolecular complex assembly

2.16E-02

vit-5

Phosphate transport

3.70E-05

rha-2

Cellular macromolecular complex assembly

2.16E-02

C06E7.1

Protein complex assembly

2.26E-02

C25H3.6*

Transcription from RNA polymerase II promoter

4.87E-02

pat-4

Chromatin assembly or disassembly

4.92E-03

C33H5.18

Chromatin assembly or disassembly

3.02E-03

unc-60

Protein complex assembly

2.26E-02

vit-2

Phosphate transport

3.70E-05

ril-1*

Cell adhesion

3.57E-02

CD4.4*

Ribosome biogenesis

1.85E-02

eif-3.F

Organelle organization and biogenesis

3.75E-03

F09F7.5*

Pigment metabolic process

5.01E-03

pab-2

Chromatin assembly or disassembly

8.99E-05

hpk-1

Growth

2.78E-02

mdh-1

Lipid metabolic process

3.36E-02

blmp-1

Chromatin assembly

7.22E-04

daf-3

Protein complex assembly

2.26E-02

F28B3.5*

Amine metabolic process

3.04E-03

rps-23

tRNA aminoacylation for protein translation

1.04E-03

F30A10.10

Chromatin assembly or disassembly

4.95E-02

dlk-1

Transcription from RNA polymerase II promoter

4.87E-02

F40F8.5*

Nucleobase metabolic process

5.08E-05

elo-5

Lipid metabolic process

4.34E-02

F43G9.3

Water-soluble vitamin metabolic process

2.04E-03

ife-1

Organelle organization and biogenesis

3.75E-03

spt-4

Chromatin assembly or disassembly

8.40E-05

aakb-1

Nucleobase, nucleoside and nucleotide metabolic process

1.45E-03

dod-22*

Gene expression

1.85E-02

F57B9.3

Amine metabolic process

2.83E-02

cdc-25.1

Amine metabolic process

1.90E-02

nac-3

Cellular macromolecular complex assembly

2.16E-02

lin-23

Cytoskeleton organization and biogenesis

2.59E-02

K10D2.2

Anion transport

5.54E-04

ifg-1

Organelle organization and biogenesis

3.75E-03

sir-2.1

Lipid transport

2.44E-04

wip-1*

Chromatin assembly or disassembly

1.99E-02

skn-1

Chromatin assembly or disassembly

3.56E-04

vha-6

Regulation of metabolic process

3.84E-02

W01B11.3

Establishment of protein localization

1.93E-04

W06B11.3*

Fatty acid metabolic process

6.78E-03

rpl-30

Chromatin assembly or disassembly

3.02E-03

tag-300

Cytoskeleton organization and biogenesis

2.59E-02

Y42G9A.4

Chromatin assembly or disassembly

3.32E-02

gdi-1

Secondary metabolic process

1.98E-02

spl-1

Sulfur metabolic process

2.33E-02

pod-1

Intracellular protein transport

2.04E-02

lrs-2

Intracellular protein transport

2.04E-02

let-60

Nucleotide-excision repair

1.11E-02

  1. The first column lists longevity genes, column 2 shows the most highly enriched Gene Ontology biological process in subnetworks containing that gene, and the P-value of the enrichment (hypergeometric test with FDR correction) is shown in column 3. Genes with no previously known manual Gene Ontology biological process annotation are indicated with an asterisk.