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Table 3 Assigning putative functions to longevity genes

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

Gene Gene Ontology biological process P-value
rpl-4 Cellular macromolecular complex assembly 2.16E-02
vit-5 Phosphate transport 3.70E-05
rha-2 Cellular macromolecular complex assembly 2.16E-02
C06E7.1 Protein complex assembly 2.26E-02
C25H3.6* Transcription from RNA polymerase II promoter 4.87E-02
pat-4 Chromatin assembly or disassembly 4.92E-03
C33H5.18 Chromatin assembly or disassembly 3.02E-03
unc-60 Protein complex assembly 2.26E-02
vit-2 Phosphate transport 3.70E-05
ril-1* Cell adhesion 3.57E-02
CD4.4* Ribosome biogenesis 1.85E-02
eif-3.F Organelle organization and biogenesis 3.75E-03
F09F7.5* Pigment metabolic process 5.01E-03
pab-2 Chromatin assembly or disassembly 8.99E-05
hpk-1 Growth 2.78E-02
mdh-1 Lipid metabolic process 3.36E-02
blmp-1 Chromatin assembly 7.22E-04
daf-3 Protein complex assembly 2.26E-02
F28B3.5* Amine metabolic process 3.04E-03
rps-23 tRNA aminoacylation for protein translation 1.04E-03
F30A10.10 Chromatin assembly or disassembly 4.95E-02
dlk-1 Transcription from RNA polymerase II promoter 4.87E-02
F40F8.5* Nucleobase metabolic process 5.08E-05
elo-5 Lipid metabolic process 4.34E-02
F43G9.3 Water-soluble vitamin metabolic process 2.04E-03
ife-1 Organelle organization and biogenesis 3.75E-03
spt-4 Chromatin assembly or disassembly 8.40E-05
aakb-1 Nucleobase, nucleoside and nucleotide metabolic process 1.45E-03
dod-22* Gene expression 1.85E-02
F57B9.3 Amine metabolic process 2.83E-02
cdc-25.1 Amine metabolic process 1.90E-02
nac-3 Cellular macromolecular complex assembly 2.16E-02
lin-23 Cytoskeleton organization and biogenesis 2.59E-02
K10D2.2 Anion transport 5.54E-04
ifg-1 Organelle organization and biogenesis 3.75E-03
sir-2.1 Lipid transport 2.44E-04
wip-1* Chromatin assembly or disassembly 1.99E-02
skn-1 Chromatin assembly or disassembly 3.56E-04
vha-6 Regulation of metabolic process 3.84E-02
W01B11.3 Establishment of protein localization 1.93E-04
W06B11.3* Fatty acid metabolic process 6.78E-03
rpl-30 Chromatin assembly or disassembly 3.02E-03
tag-300 Cytoskeleton organization and biogenesis 2.59E-02
Y42G9A.4 Chromatin assembly or disassembly 3.32E-02
gdi-1 Secondary metabolic process 1.98E-02
spl-1 Sulfur metabolic process 2.33E-02
pod-1 Intracellular protein transport 2.04E-02
lrs-2 Intracellular protein transport 2.04E-02
let-60 Nucleotide-excision repair 1.11E-02
  1. The first column lists longevity genes, column 2 shows the most highly enriched Gene Ontology biological process in subnetworks containing that gene, and the P-value of the enrichment (hypergeometric test with FDR correction) is shown in column 3. Genes with no previously known manual Gene Ontology biological process annotation are indicated with an asterisk.