Skip to main content

Advertisement

Table 1 Gene Ontology biological process categories enriched in the set of genes represented in modular subnetworks

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

Gene Ontology biological process P-value
Translation 6.45E-17
Hermaphrodite genitalia development 1.20E-16
Embryonic cleavage 1.37E-15
Germline cell cycle switching, mitotic to meiotic cell cycle 8.32E-14
Locomotory behavior 1.84E-13
Meiosis 1.10E-11
Positive regulation of multicellular organism growth 4.25E-11
Morphogenesis of an epithelium 3.85E-06
Protein catabolic process 1.13E-05
Phosphate transport 4.99E-04
Negative regulation of multicellular organism growth 8.07E-04
Ubiquitin-dependent protein catabolic process 1.94E-03
Nucleosome assembly 1.97E-03
Establishment of nucleus localization 2.37E-03
Tricarboxylic acid cycle 3.26E-03
DNA replication 4.64E-03
Protein transport 5.01E-03
Energy coupled proton transport, against electrochemical gradient 5.02E-03
Leucyl-tRNA aminoacylation 5.02E-03
Collagen and cuticulin-based cuticle development 5.12E-03
Organelle organization and biogenesis 5.19E-03
Chromosome segregation 7.48E-03
mRNA metabolic process 8.44E-03
Protein import into nucleus 1.15E-02
Purine base biosynthetic process 1.15E-02
Sulfur compound biosynthetic process 1.40E-02
DNA repair 1.45E-02
Determination of adult life span 1.74E-02
Threonine metabolic process 1.75E-02
Water-soluble vitamin biosynthetic process 1.78E-02
ATP synthesis coupled proton transport 3.14E-02
rRNA processing 3.85E-02
Isoleucyl-tRNA aminoacylation 4.02E-02
Methionyl-tRNA aminoacylation 4.02E-02
Valyl-tRNA aminoacylation 4.02E-02
Embryonic pattern specification 4.04E-02
Regulation of cell cycle 4.04E-02
  1. All categories shown are significant at P < 0.05 after an FDR correction for multiple testing. GO categories written in italics are also enriched for known longevity genes (Additional file 4).