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Figure 5 | Genome Biology

Figure 5

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

Figure 5

Subnetworks and genes predict the age of fer-15 worms. Modular subnetworks are shown in green, regular subnetworks in blue, and gene sets in gray. This figure shows the best-performing type of modular subnetworks, regular subnetworks, and genes at each feature level. For modular subnetworks, this is type m3 at every feature level; for regular subnetworks, type r3 at 5 and 10 features, r2 at 25 features, and r4 at 50 features; for genes, g2 at all feature levels. Support vector regression algorithms using 5, 10, 25, or 50 features were trained to predict age on the data from Golden et al. [2] and tested on Budovskaya et al. [21]. For each size of feature set, 1,000 different support vector regression learners were computed; curves show their median performance (quantified using the squared correlation coefficient (SCC) between true and predicted age in the bottom panel), and error bars indicate the 95% confidence intervals for the medians (calculated using a bootstrap estimate).

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