Figure 2

Within large LEM-2 domains, a finer level of organization consists of LEM-2 subdomains and gaps. (a,b) Representative LEM-2 subdomains on chromosomes IV (a) and V (b). Top panels with box indicate the chromosomal positions of regions shown below. Vertical bars in the tracks indicate ChIP-chip MA2C scores (-2 to 2) or ChIP-seq z-scores (-2 to 2). (c) Size distribution of LEM-2 subdomains and gaps. Subdomains or gaps were binned according to their size (log₁₀ scale), and the number of regions for each bin are plotted. (d) Relationship between chromosome size and LEM-2 occupancy (total base pairs of LEM-2 subdomains divided by chromosome size (bp)). The line indicates a linear regression for autosomes by the least squares fit (intercept, 31.4; slope, 1.48).