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Figure 4 | Genome Biology

Figure 4

From: Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level

Figure 4

Association with BMI. (a) Significance of the association with BMI identified by single marker tests (-log10(chi-square P-value)) for all SNVs located in the MGLL interval (x-axis, NCBI36 coordinates). SNPs with a P-value < 0.01 are highlighted in red. The recombination rate [56] in the HapMap CEU population for this region is indicated by a blue line and measured on the right axis. (b,c) Significance of the association with BMI for all locus-variants identified by RareCover (see Materials and methods) in the MGLL (a) and FAAH (b) sequenced intervals. For both genes, locus-variants with a P-value < 0.01 are highlighted in red. The MGLL and FAAH gene structures are aligned based on their genomic positions.

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Genome Biology

ISSN: 1474-760X

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