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Table 3 Comparisons between fish and human metabolic pathways

From: Constructing a fish metabolic network model

Most conserved pathways
Pathway Human ECs Fish ECs Overlap Ratio
1- and 2-Methylnaphthalene degradation 2 3 2 1
Hyaluronan metabolism 3 3 3 1
Sialic acid metabolism 18 18 18 1
Hexose phosphorylation 5 5 5 1
Electron transport chain 4 5 4 1
Limonene and pinene degradation 3 4 3 1
Proteoglycan biosynthesis 16 16 16 1
Glycosphingolipid biosynthesis - ganglioseries 18 17 17 0.94
N-Glycan degradation 8 7 7 0.87
Di-unsaturated fatty acid beta-oxidation 7 6 6 0.85
Vitamin B1 (thiamin) metabolism 7 6 6 0.85
Glycosphingolipid metabolism 28 24 24 0.85
Glutamate metabolism 14 12 12 0.85
TCA cycle 18 15 15 0.83
Vitamin B9 (folate) metabolism 17 14 14 0.82
Linoleate metabolism 11 9 9 0.81
Least conserved pathways
Pathway Human ECs Fish ECs Overlap Ratio
Phytanic acid peroxisomal oxidation 13 5 5 0.38
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 3 1 1 0.33
Vitamin H (biotin) metabolism 6 2 2 0.33
Vitamin B12 (cyanocobalamin) metabolism 3 2 1 0.33
Glyoxylate and Dicarboxylate metabolism 7 2 2 0.28
Pentose and Glucuronate interconversions 9 2 2 0.22
Ascorbate (vitamin C) and aldarate metabolism 8 1 1 0.12
  1. The ratio is the number of shared ECs over the number of human ECs. Only pathways with three or more enzymes were considered. The complete comparison is given in Additional file 9. Please see Discussion section on the bias towards human data. The sizes of fish pathways may grow with improved annotation, but this is unlikely to change the ratios because all overlapping enzymes are already included here.