Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing

Table 1 Statistics of exome sequencing and reads mapping

	HCC1954	HCC1954BL
Number of 454 reads	6,878,120	6,658,357
Total bases pairs	2,588,213,873	2,325,966,906
Uniquely mapped reads	6,645,304 (97%)	6,385,651 (96%)
Reads uniquely mapped to primary targets	4,806,828 (70%)	4,310,274 (65%)
Target coverage	94.8%	96.0%
Mean target coverage	19.4×	18.1×
Median target coverage	16×	16×
Coverage enrichment by exome sequencing	23×	24×
Total high-confidence (HC) SNVs (known SNVs)	13,102 (12,145)	14,219 (13,309)
HC heterozygous SNVs (known SNVs)	5,602 (4,954)	8,203 (7,408)
HC heterozygous SNVs in CDS (known SNVs)	5,329 (4,709)	7,848 (7,082)

ISSN: 1474-760X