Figure 1

Variance in weights of mice haploinsufficient for Dnmt3a. (a) Mice from paternal and maternal transmission of the Dnmt3a^- null allele and the Dmnt1^MommeD2 allele were weighed and genotyped at 3 weeks of age (weaning). The data presented in these graphs are tabulated below. (b) There is significantly more variation in the weights of Dnmt3a^-/+ mice following paternal transmission of the mutant allele (F test, P = 0.01). Dnmt3a^- data were collected from wild-type and heterozygous mutant littermates from a wild-type x heterozygous cross. Dmnt1^MommeD2 data were collected from wild-type x heterozygous crosses (equal contributions from reciprocal crosses) and heterozygous intercrosses.