Histone modification signals aligned at TSSs (promoters) and distal p300 binding sites (enhancers). Scaled signals of 100 promoter and enhancer regions with strong histone modification (sequencing read counts higher than an arbitrary cutoff) and the highest PSSM scores of Oct4 are plotted (see Materials and methods for how these regions were selected and Figure S1 in Additional file 1 for plots of other TFs). Individual histone marks are shown in a heatmap (upper panels) and the averaged signal is shown in the lower panels. TSSs are ordered by gene expression and the p300 binding sites are ordered using ChIP tag counts. Both are in descending order from the top to the bottom.