miR-122 targeting HCV. The HCV RNA genome is shown with coding regions as rectangles and the 5' and 3' UTRs as lines. Structural genes are in blue and non-structural genes in purple. The two seed matches bound by miR-122 are highlighted in red in an expanded view of the 5' UTR. The sequence of miR-122 is shown in black, with the seed (nucleotides 2-8) in red. The SPC3649 molecule that targets it is shown with LNA indicated in orange (C in orange indicates LNA methylcytosine) and DNA in green. The backbone is phosphorothioate.