Figure 2

The extracellular LRR and IgSF neuroreceptor interaction network. Receptors belonging to the same paralogous subfamily are grouped and shaded within the network, and interactions classified according to confidence: thick lines = interaction detected in the primary screen and independent of bait/prey orientation; thin line = other detected interactions, including those that are orientation dependent - see Materials and methods and Additional data file 6 for full details. An orange line indicates that the interactions were validated using an independent technique, either surface plasmon resonance (Figure 3) or a bead-binding assay (Additional data file 2). IgSF-receptors = blue nodes, LRR-receptors = red nodes.