Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae

Table 4 Genes required for expression of specific mitochondrial translation products

*YAL039c	CYC3	Cytochrome c heme lyase
YDR197c	CBS2	Mitochondrial translational activator of the COB mRNA
*YEL051w	VMA8	Subunit D of the vacuolar H⁺-ATPase (V-ATPase)
YGR222w	PET54	Binds to the 5' untranslated region of the COX3 mRNA to activate its translation; also binds to the COX1 group I intron AI5 beta to facilitate splicing
YIR021w	MRS1	Required for the splicing of two mitochondrial group I introns
*YJL062w-a	RRG10	Protein of unknown function
YLR203c	MSS51	Required for translation of COX1 mRNA
YMR282c	AEP2	Likely involved in translation of the mitochondrial ATP9 mRNA
YNR045w	PET494	Mitochondrial translational activator specific for the COX3 mRNA
*YOL096c	COQ3	Component of a mitochondrial ubiquinone-synthesizing complex

The list indicates systematic and standard names of genes required for synthesis of only a subset of mitochondria-encoded proteins. The cellular roles of the proteins are indicated according to the Saccharomyces Genome Database [19] or manually annotated. Genes that were previously not known to be required for expression of specific mitochondrial translation products are highlighted with an asterisk.

ISSN: 1474-760X